My group’s current work focuses on identifying cellular genes that are necessary for the JC virus life cycle. JCV is a human polyoma virus that is the cause of progressive multifocal leucoencephalopathy in TYSABRI-treated multiple sclerosis patients.

I am currently a member of the Journal of Virology editorial board. I earned my Ph.D. in immunology elucidating the molecular requirement for CD45 in T cell receptor signal transduction. I discovered that CD45 primes LCK and Fyn kinase activity in resting T cells to be responsive to receptor engagement. I spent the next 15 years studying the molecular mechanism of Epstein-Barr virus transformation. EBV is a large herpes virus that expresses LMP1 and LMP2 which mimic CD40 and BcR to drive B cell proliferation. My group demonstrated that EBV LMP1 mediated NFkB activation is required for GLUT1 trafficking to the plasma membrane and the associated increase in glucose import necessary to support B cell proliferation.

Education

  • Postdoctoral Fellow, Brigham and Women’s Hospital, Boston, MA, 2001
  • Ph.D., Washington University, St. Louis, MO, 1996
  • B.S., University of California, Los Angeles, CA, 1989

Selected Publications

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