The research of my group at Biogen is focused on exploring the role of TDP-43 in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) and amyotrophic lateral sclerosis. The field is evolving around the role of TDP-43 in disease pathogenesis, and our group’s research is focused on unraveling the basic biology of this intriguing new player in neurodegenerative disease. We use both in vitro and in vivo models with an aim to dissect the toxic gain-of-function vs. loss-of-function properties of TDP-43, and to determine whether preventing TDP-43 aggregation would be of therapeutic benefit.

The role of protein misfolding in neurodegenerative disease continues to be a major interest of mine, after more than 10 years of research experience. Prior to joining Biogen in 2011, my previous academic research focused on the role of ABeta seeds in the spread of amyloid pathology in transgenic mouse models of Alzheimer’s disease, and developing mouse models for familial British and Danish dementia at the University of Tuebingen, Germany.

Education

  • Postdoctoral Fellow, University of Tuebingen, Germany, 2011
  • Ph.D., Neurology, University of Tuebingen, Germany, 2009

Selected Publications

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