My research interests at Biogen focus on the applications of mass spectrometry in neurology, immunology and tissue fibrosis research. Within these projects, we collaborate with the biologists in these therapeutic areas in pursuit of unknown receptors for proteins of therapeutic interest and viruses. We explore the mechanism of actions of drugs and drug candidates by analyzing drug-protein interactions (chemical proteomics), protein complexes, signaling pathways and their alterations under the influence of external stimuli or drug treatment.

We are continuously looking into novel technologies for improving the depth, quality and speed of proteomics analyses. The major directions of technology development include analytical workflows for rare cell populations enriched by laser-capture microdissection or FACS (proteomics, lipidomics), expanding the utility of chemical proteomics from cellular systems to animal studies (in vivo chemical proteomics), and development of massively multiplexed protein, metabolite and lipid assays (>1000-plex) for fast profiling of analyte signatures in cell-based studies. In addition to these areas, we also operate state-of-the-art mass spectrometric imaging capabilities with multiple modalities of imaging.

I graduated from the Eötvös Loránd University in Budapest, Hungary. Following my postdoctoral term in Klaus Biemann’s lab at MIT, I held various industrial positions at PerSeptive Biosystems, Applied Biosystems and BG Medicine. Areas of activities included mass spectrometric characterization of peptide, protein and carbohydrate structures, development of novel mass spectrometric technologies (such as delayed extraction MALDI TOF and TOF/TOF with Marvin Vestal) and novel quantitative proteomics methodologies such as iTRAQ with Darryl Pappin. I have extensive experience with mass spectrometry–based biomarker workflows in proteomics, metabolomics and lipidomics.

Education

  • Postdoctoral Fellow, Biological Mass Spectrometry, MIT, Cambridge, MA, 1992
  • Ph.D., Physical Chemistry, Mass Spectrometry, Eötvös Loránd University, Budapest, Hungary, 1986
  • M.S., Physical Chemistry, Eötvös Loránd University, Budapest, Hungary, 1982

Selected Publications

See more scientists