Powered by the world’s leading scientists
- All Scientists
- Joe Arndt
- Moore Arnold
- Bekim Bajrami
- Linda Burkly
- Thierry Bussiere
- Ellen Cahir-Mcfarland
- Thomas Cameron
- John Carulli
- Janaky Coomaraswamy
- Mark Cosentino
- Olivier Danos
- Nathan Donelson
- Anthone Dunah
- Chris Ehrenfels
- Istvan Enyedy
- Agnès Gardet
- Davide Gianni
- Jaya Goyal
- Stefan Hamann
- Chris Henderson
- Xiaoping Hronowski
- Ron Huang
- Peter Juhasz
- Mark Kankel
- Maria Lalioti
- Doug Larigan
- Kejie Li
- Edward Lin
- John Lydeard
- Jeffrey Martin
- Alexander McCampbell
- Amy McCurley
- Sha Mi
- Alvydas Mikulskis
- Michaël Mingueneau
- Sarav Narayanan
- Karel Otero-Gutierrez
- Robert Blake Pepinsky
- Rob Peters
- Martin Preyer
- Dania Rabah
- Richard Ransohoff
- Shuyu Ren
- Mia Rushe
- Sarah Ryan
- Anindya Sen
- Chase Shen
- Laura Silvian
- Benjamin Smith
- John Staropoli
- Christopher Stebbins
- Lauren Stevenson
- Meena Subramanyam
- Chao Sun
- Sai Thankamony
- Kien Trinh
- Antonio Valencia
- Qin Wang
- Dong Wei
- Ru Wei
- Andreas Weihofen
- Paul Weinreb
- Brian Wipke
- Guangqing Xiao
- Zhili Xin
Our group uses Drosophila melanogaster (the fruit fly) to explore the interactions between genes and environmental cues and how these interactions influence the development of neurodegenerative diseases. To this end, we are conducting genetic experiments to better understand the molecular mechanism of neurodegenerative disorders. We are utilizing morphological and behavioral changes as markers for neurological dysfunction in the intact animals. We also employ high-resolution imaging techniques and electrophysiological recordings to monitor changes at the cellular level to assess neuronal functions. The goal is to translate discoveries in fruit flies to mammalian models of neurodegeneration for discovery and development of target therapeutics.
Prior to joining Biogen, I did my post-graduate training with Dr. Leo Pallanck at the University of Washington. I created fly transgenic models of Parkinson’s disease (PD) and interrogated the molecular mechanisms that underlie neuronal death in PD. Using a transgenic fly model expressing the human alpha-synuclein, a key component of Lewy bodies in PD brains, I performed a genetic screen and showed that genes involved in glutathione (GSH) metabolism modify neuronal health. Also, environmental factors that enhance GSH production can be beneficial to dopamine neurons. My work also included modeling Gaucher’s disease, a lysosomal storage disorder, in the fly and interrogating the effect of mitochondria DNA mutations on disease and aging. My graduate work focused on the molecular mechanisms that underlie long-term adaptation in sensory neurons to understand the cellular mechanism of odorant detection. This led to the creation and analysis of an adenylyl cyclase type III (AC3) knockout mouse. AC3 is a key cAMP-generating enzyme in olfactory neurons and AC3 knockout animals are anosmic.
- Ph.D., University of Washington, Seattle, WA - 2003
- M.S., San Diego State University, San Diego, CA - 1995
- B.S., San Diego State University, San Diego, CA - 1992
- Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism.
J Neurosci. 2010 Apr 21;30(16):5525-32. doi: 10.1523/JNEUROSCI.4777-09.2010.
Trinh K, Andrews L, Krause J, Hanak T, Lee D, Gelb M, Pallanck L.
- Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.
J Neurosci. 2008 Jan 9;28(2):465-72. doi: 10.1523/JNEUROSCI.4778-07.2008.
Trinh K, Moore K, Wes PD, Muchowski PJ, Dey J, Andrews L, Pallanck LJ.
- Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.
Gene Expr Patterns. 2007 Feb;7(4):413-22. Epub 2006 Nov 26.
Hess NK, Singer PA, Trinh K, Nikkhoy M, Bernstein SI.
- Detection of odorants through the main olfactory epithelium and vomeronasal organ of mice.
Nutr Rev. 2004 Nov;62(11 Pt 2):S189-92; discussion S224-41.
Trinh K, Storm DR.
- Odorant stimulation enhances survival of olfactory sensory neurons via MAPK and CREB.
Neuron. 2004 Mar 25;41(6):955-67.
Watt WC, Sakano H, Lee ZY, Reusch JE, Trinh K, Storm DR.
- Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.
Dev Biol. 2003 Jun 15;258(2):385-96.
Horner K, Livera G, Hinckley M, Trinh K, Storm D, Conti M.
- Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium.
Nat Neurosci. 2003 May;6(5):519-25.
Trinh K, Storm DR.
- Adenylyl cyclase 3 mediates prostaglandin E(2)-induced growth inhibition in arterial smooth muscle cells.
J Biol Chem. 2001 Sep 7;276(36):34206-12. Epub 2001 Jun 29.
Wong ST, Baker LP, Trinh K, Hetman M, Suzuki LA, Storm DR, Bornfeldt KE.
- SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation.
EMBO J. 2000 Sep 15;19(18):4955-66.
Poser S, Impey S, Trinh K, Xia Z, Storm DR.
- Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.
Neuron. 2000 Sep;27(3):487-97.
Wong ST, Trinh K, Hacker B, Chan GC, Lowe G, Gaggar A, Xia Z, Gold GH, Storm DR.
- Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family.
J Biol Chem. 1996 Aug 9;271(32):19415-20.
Hu B, Trinh K, Figueira WF, Price PA.